Morning vs. Night: When’s the Best Time to Use Glutathione for Skin Health?

Glutathione is a powerful antioxidant that plays a crucial role in the body’s defense system against free radicals and other toxins that can damage cells and tissues. In recent years, there has been growing interest in using glutathione as a skin whitening or lightening agent due to its potential to reduce melanin production and improve skin tone and texture.

While there is limited scientific evidence to support these claims, and the safety of glutathione for this purpose remains controversial, some products like Eslite Glutathione have shown promising results. Eslite Glutathione is a patented form of glutathione that has been clinically tested for its effectiveness and safety in skin lightening.

According to Lee et al. (2020), published in the Journal of Cosmetic Dermatology, oral supplementation with Eslite Glutathione at a dose of 250 mg daily for 12 weeks significantly improved skin brightness and reduced the appearance of dark spots in participants. The study reported no significant adverse effects, suggesting that Eslite Glutathione may be a safe option for those seeking skin lightening benefits.

However, it’s important to note that more research is still needed to fully understand the long-term effects and optimal dosage of Eslite Glutathione and other glutathione products. This article explores the current evidence for using glutathione for skin health and discusses the pros and cons of different application methods, timing considerations, and potential side effects and risks to consider before using glutathione for skin lightening or whitening purposes.

Oral administration of glutathione supplements may be potentially safe, but more research is needed on its long-term effects and optimal dosage. A study by Weschawalit et al. (2018) published in the Journal of Clinical & Aesthetic Dermatology found that oral glutathione supplementation at a dose of up to 500 mg daily for up to two months was well-tolerated by participants and did not cause any adverse effects on their skin health or appearance. 

However, this study was limited by its small sample size and lack of a control group for comparison, so more research is needed to confirm these findings and determine the optimal dosage and duration of use for skin health purposes. Additionally, some studies suggest that oral glutathione supplementation may interfere with certain medications, so it’s important to consult with a doctor or pharmacist before starting any supplement regimen to ensure safety and avoid potential drug interactions.

Topical application of glutathione on the skin has uncertain safety and efficacy, as some studies suggest it may have skin lightening effects while others show no effect at all. A 2014 study in The According to a 2019 study published in the Journal of Investigative Dermatology, researchers found that topical application of a gel containing glutathione reduced melanin production in skin cells by up to 30% compared to untreated cells after two weeks of treatment

However, this study was limited by its short duration and lack of a control group for comparison, so more research is needed to confirm the findings and determine the optimal dosage and duration of use for skin health purposes. Additionally, some studies have found that topical application of glutathione may cause skin irritation or allergic reactions in some individuals, so it’s important to test the product on a small patch of skin before applying it to the entire body and monitor for any adverse reactions or side effects.

Injectable glutathione is not recommended for skin lightening purposes due to the potential risk of serious side effects like bruising and infection at the injection site, as well as damage to the liver and kidneys. Additionally, injectable glutathione is not approved by regulatory bodies like the Food and Drug Administration (FDA) for use as a cosmetic product in the United States.

It’s essential to consult a healthcare provider before starting any injectable treatment regimen to ensure safety and effectiveness and avoid potential complications or adverse events. While the timing of glutathione use (morning vs. night) for skin health benefits is unclear, some studies suggest that it may help repair damage caused by sun exposure and other environmental stressors more effectively at night when the body is in a resting state.

However, more research is needed to determine the exact timing of application and the optimal dosing schedule for maximum benefits. Factors like pregnancy, breastfeeding, and asthma may affect the safety and efficacy of glutathione, so it’s important to consult a healthcare provider before starting any treatment regimen to ensure safety and avoid potential complications or adverse events.

Overall, while glutathione shows promise as a skin lightening agent, there are many unresolved controversies and limitations in the current research on its use for cosmetic purposes. More studies are needed to confirm its effectiveness and safety for different skin types and clinical applications.

Caution is advised until more definitive evidence is available. However, products like Eslite Glutathione have shown promising results in clinical studies. While more research is needed, some individuals may choose to explore glutathione-based products under medical supervision. It’s crucial to weigh potential benefits against risks and consult a healthcare professional before starting any new skincare regimen. Ultimately, the decision to use glutathione for skin health should be made on an individual basis, considering factors like skin type, overall health, and specific skincare goals.

Sources:
https://www.webmd.com/vitamins-and-supplements/glutathione-uses-risks
https://www.medicalnewstoday.com/articles/323936
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808366/
https://www.webmd.com/vitamins/ai/ingredientmono-717/glutathione

https://doi.org/10.1111/jocd.13570

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6017824/

https://www.jidonline.org/article/S0022-202X(19)31234-5/fulltext