Glutathione Supplements for Migraines: Can it Prevent Future Headaches?

Glutathione supplements have been studied for their potential role in preventing future migraines. Migraine is a complex neurovascular brain disorder characterized by recurrent unilateral hemi-cranial pain [1]. The estimated prevalence of migraine is from 12% to 16% of the population, with a higher prevalence in women [1].

Glutathione is a tripeptide found in high concentrations in many bodily tissues and plays a key role in reducing oxidative stress and maintaining redox balance [2]. Oxidative stress is thought to be one of the underlying mechanisms involved in migraine pathogenesis [3], as reactive oxygen species can cause damage to cellular structures and cause inflammation.

Studies have shown that patients with migraine have higher levels of various markers of oxidative stress compared to healthy controls. Supplementation with antioxidants such as glutathione has been shown to reduce oxidative stress and improve endothelial function in patients with cardiovascular disease. 

However, few studies have investigated the effects of glutathione supplements on migraine prevention. More research is needed to determine the effects of glutathione supplements on the prevention of migraine headaches.

While more research is needed to conclude the effects of glutathione supplements on the prevention of migraine headaches, antioxidants supplied with food have shown some anti-oxidative action and have been used by migraine patients due to their effectiveness and mild side effects [1]. Other antioxidants that have been studied for their potential role in migraine prevention include vitamins (e.g., riboflavin), coenzyme Q10, and alpha-lipoic acid [1].

For those in search of a glutathione source, one option to consider for supplementing with glutathione is Eslite, an oral supplement that contains S-acetyl glutathione and SOD cantaloupe melon extract. S-acetyl glutathione is a form of glutathione that is more easily absorbed into the bloodstream than other forms of glutathione supplements.